一个关于SSRI和心血管疾病和抑郁症患者血压之间的关联的元分析
Lijun Zhang1, Guo Li1, Meiyan Liu1
1Department of Psycho-cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Journal of affective disorders
|August 9, 2023
概括
选择性血清素再吸收抑制剂 (SSRI) 在大多数心血管疾病和抑郁症患者中没有影响血压. 然而,在患有抑郁症的高血压患者中,SSRI显著降低了透静血压.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 心血管疾病 (CVD) 和抑郁症经常同时存在.
- 选择性血清素再吸收抑制剂 (SSRI) 通常用于治疗抑郁症.
- 抑郁症心血管疾病患者SSRI对血压的影响需要澄清.
研究的目的:
- 在患有心血管疾病和抑郁症的患者中对SSRI和血压之间的关联进行元分析.
- 评估SSRI对静脉压 (SBP) 和静脉压 (DBP) 的影响.
主要方法:
- 在PubMed,Web of Science和EMBASE数据库的系统文献搜索,截至2022年10月26日.
- 六项涉及149名心血管疾病和抑郁症患者的研究的元分析.
- 使用Review Manager 5.3和Stata 12.0进行数据分析,并遵循PRISMA 2020指南.
主要成果:
- 在整体组分析中,SSRI对SBP或DBP没有显著影响.
- 亚组分析显示,高血压患者或其他心血管疾病患者对SBP没有显著影响.
- 在患有抑郁症的高血压患者中,SSRI显著降低了DBP (MD = -5.75,95%CI: -10.84, -0.67),但在其他心血管疾病患者中没有.
结论:
- 在患有抑郁症的高血压患者中,SSRI可能有助于降低腹压血压.
- 潜在的机制包括血清素功能,交感激活和遗传因素.
- 需要进一步的临床和实验研究来阐明SSRI和血压之间的关系.
相关概念视频
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
438
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
438
Antidepressant Drugs: MAOIs and Other Agents
274
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
274
Disorders of the Autonomic Nervous System
703
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
703
Psychoneuroimmunology: Cardiovascular Disease
51
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
51
Antidepressant Drugs: Overview
570
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
570
Factors affecting Blood pressure
3.3K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
3.3K


