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严重的食物过敏反应与α-tryptase相关
Abigail Lang1, Stephanie Kubala2, Megan C Grieco3
1Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill; Northwestern University Feinberg School of Medicine, Chicago, Ill.
阿尔法酸酶的存在与更严重的食物过敏反应有关. 这一发现强调了α-酸酶作为评估食物过敏严重程度和过敏反应风险的潜在生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 编码alpha-tryptase的TPSAB1副本数量的增加与虫毒素过敏,全身巨细胞瘤和异常性过敏症的严重反应有关.
- 阿尔法-酸酶在过敏反应中起作用.
研究的目的:
- 为了研究α-酸酶与食物过敏反应的严重程度之间的关联.
- 为了确定alpha-tryptase是否可以作为食物过敏严重程度的生物标志物.
主要方法:
- 对来自食物过敏队列的119名受试者进行了三酶基因定型.
- 阿尔法酸酶的存在被评估为食物过敏严重程度的预测指标.
- 使用标准化得分 (Bock/PRACTALL和SGSAR) 测量了食物过敏反应的严重程度.
主要成果:
- 在一个队列中,α-tryptase的存在与食物触发的过敏反应的更高患病率有关 (P = .026).
- 在另一个队列中,与没有 (17%) (P = .066) 相比,服用阿尔法酸酶的受试者出现严重反应的比率显著更高 (65%).
- 更高的α-tryptase异形拷贝数与严重性得分的增加相关 (SGSAR和Bock/PRACTALL) (P = .008和P = .003,分别).
结论:
- 阿尔法三酶的存在与过敏反应和对食物的严重反应的患病率增加有关.
- 阿尔法三酶可能是预测食物过敏严重程度的有价值生物标志物.
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