母亲的维生素D相关代谢和后代的喘风险结果
Min Kim1, Nicklas Brustad2, Mina Ali2
1Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Faculty of Health and Biomedical Science, University of Surrey, Guildford, United Kingdom.
较高的妊娠维生素D水平与特定的母体代谢变化有关,特别是在基米林通路中. 这些变化与儿童早期经常出现喘息和喘恶化的风险降低有关.
科学领域:
- 产周医学 产周医学
- 代谢学 代谢学 代谢学
- 呼吸系统健康 呼吸系统健康
背景情况:
- 孕期维生素D缺乏与后代的呼吸系统疾病有关.
- 基本的机制仍然在很大程度上是未知的.
研究的目的:
- 调查怀孕期间母亲维生素D水平与儿童喘表型之间的关联.
- 利用母亲的血液代谢学来发现潜在的机制.
主要方法:
- 分析了来自两个大型母婴队列 (COPSAC2010和VDAART) 的非向血液代谢.
- 采用多变量模型和途径丰富分析来识别与维生素D相关的代谢物和途径.
- 在单独的队列和体外细胞模型中验证的结果.
主要成果:
- 较高的母体维生素D水平与明显的代谢特征相关,特别是涉及基米林通路.
- 这种母体代谢特征与后代 (0-3岁) 经常出现喘息和喘恶化的风险降低有关.
- 在体外研究表明,维生素D3在支气管上皮细胞中的脂水平增加.
结论:
- 孕产妇的新陈代谢变化,特别是在基米林通路内,标志着孕期维生素D对后代呼吸系统健康的保护作用.
- 这项研究为将母亲的维生素D状况与儿童喘联系在一起的机制提供了新的见解.
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