皮层厚度的地形相似性代表了青春期青少年普遍的焦虑症状
1Department of Psychology, Sungkyunkwan University, Seoul 03063, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, South Korea.
Brain research bulletin
|August 9, 2023
概括
通用焦虑障碍 (GAD) 涉及过度担心. 这项研究在患有高GAD症状的青少年中发现了特定的大脑皮层模式,突出显示了大脑结构中独特的地形联系.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 一般性焦虑症 (GAD) 很普遍,以过度担忧和高并发症为特征.
- 关于GAD神经基础的神经成像研究,特别是皮质厚度,已经显示出不一致的结果.
- 了解GAD的神经生物学对于有效的干预至关重要.
研究的目的:
- 调查青少年的顶点智能皮质厚度和通用焦虑症状严重程度之间的非线性关系.
- 为了确定特定的大脑区域和与GAD症状相关的皮质地形图案.
- 探索年龄范围对观察到的关联的影响.
主要方法:
- 利用了一个跨主体的代表性相似性分析框架.
- 分析了来自健康大脑网络数据集的120名青少年 (13-18岁) 的数据.
- 检查了与一般焦虑症症状严重程度相关的顶点智能的皮质厚度.
主要成果:
- 在青少年中发现左尾前带状皮和皮皮层具有更大的地形相似性,这些青少年具有更高的泛性焦虑症状.
- 控制年龄,性别,ADHD和GAD诊断后,结果保持一致.
- 当包括年轻参与者 (11-12岁) 时,没有发现关联,强调年龄特异性.
结论:
- 确定了一种与青少年普遍焦虑相关的新型皮质厚度拓.
- 这些发现表明,GAD症状和皮层厚度模式之间有共同的几何特征.
- 突出了年龄范围选择在焦虑神经成像研究中的关键作用.
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