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抗体对神经元的结合在隔离过程中可能会受到低pH压力的影响

Wei Zhang1, Chaitanya Joshi1, Chad Smith1

  • 1Department of Neurology, Department of Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, United States of America.

Journal of immunological methods
|August 9, 2023
PubMed
概括

在抗体净化期间的酸化可能会损害多发性硬化症 (MS) 研究中的神经元结合. 这会影响具有较低CDR3电荷的重组人体抗体 (rhAbs),影响它们向神经元抗原的能力.

关键词:
抗体抗原相互作用抗体分离的隔离方法在CDR3充电时,CDR3充电.神经元结合的结合方式

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Immunoprecipitation01:20

Immunoprecipitation

Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...