相关实验视频
Updated: Jul 19, 2025

06:15
Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
12.0K
探讨在深层欧性溶剂中异氧化基因素溶解和释放的机制
Yi Hu1, Peiyi Liang1, Zhuxian Wang1
1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, PR China.
International journal of pharmaceutics
|August 9, 2023
概括
深度浸泡溶剂 (DESs) 显著提高异基原蛋白 (ISL) 溶解度,改善药物输送. 本研究探讨了ISL溶解和释放机制在新的DES配方中,以获得更好的治疗应用.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 计算化学计算化学
背景情况:
- 单离子素 (ISL) 具有宝贵的药理性质,但具有较差的水溶性,限制了其临床使用.
- 深度欧性溶剂 (DESs) 提供了一种有前途的方法来克服难以溶解化合物的溶解性挑战.
研究的目的:
- 用基于胆化物 (ChCl) 的DESs来研究ISL的溶解和释放机制.
- 探索 ChCl-OA/MA/GA DESs 和eutectogels 的潜力,以提高ISL的提供.
主要方法:
- 合成ChCl-OA/MA/GA DESs,并对ISL溶解度进行表征.
- 差分扫描热度计 (DSC) 用于测量热力学特性,光谱学和分子动力学 (MD) 模拟用于分子相互作用.
- 在实验室中使用Carbomer 940和动力建模进行药物释放研究.
主要成果:
- 与水溶液相比,ISL溶解度在ChCl-OA/MA/GA DES中显著增加 (30,073至68,103倍).
- MD模拟表明,增强的ISL-溶剂相互作用可以提高溶解度.
- 来自eutectogels的ISL释放遵循一个具有高相关系数 (0.98120.9961) 的第一阶动力模型.
结论:
- Cl-OA/MA/GA DES是ISL的有效溶解剂.
- 了解ISL-DES相互作用对于优化药物溶解性至关重要.
- 这项研究提供了一种新的策略,用于开发改善的配方,用于像ISL这样的溶性较差的药物.
相关概念视频
Energetics of Solution Formation
6.8K
The formation of a solution is an example of a spontaneous process, which is a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent...
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent...
6.8K
Chemical and Solubility Equilibria
4.1K
The free energy change associated with dissolving a solute in a liter of solvent is called the free energy of a solution, ΔGsolution. The overall ΔGsolution is expressed as the balance of ΔGinteraction against the always-favorable free-energy of mixing, ΔGmixing. Solution formation is favorable if ΔGsolution is less than zero, whereas it is unfavorable if ΔGsolution is greater than zero. In short, for a solution to form and complete dissolution to take place,...
4.1K
Theories of Dissolution: Diffusion Layer Model
809
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
809
Entropy and Solvation
7.1K
The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ...
7.1K
Extraction: Advanced Methods
485
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
485
Solution Formation
31.8K
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride.
This selective...
This selective...
31.8K

