意大利严重喘网络 严重喘临床缓解的定义:德尔菲共识
Giorgio Walter Canonica1, Francesco Blasi2, Giovanna Elisiana Carpagnano3
1Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
The journal of allergy and clinical immunology. In practice
|August 9, 2023
概括
专家们在使用德尔菲方法来定义严重喘缓解方面达成共识. 这种共识为评估严重喘患者治疗疗效提供了有价值的工具.
科学领域:
- 肺部病理学 肺部病理学
- 临床医学 临床医学
- 呼吸系统研究 呼吸系统研究
背景情况:
- 严重的喘影响了10%的喘患者,其特征是肺功能不佳和高血白细胞计数 (乙氨基).
- 目前关于喘缓解的定义 (临床,炎症,完全) 缺乏标准化.
- 意大利严重喘网络 (SANI) 登记册包括57个中心的2200多名患者.
研究的目的:
- 建立一个关于严重喘缓解的共识定义.
- 开发一种标准化,易于使用的工具,用于评估严重喘治疗的疗效.
主要方法:
- 采用了Delphi方法,涉及80名专家小组.
- 采用了两轮问卷 (R1和R2) 与利克尔特比例协议评级.
- 专家们就完全和部分临床缓解的标准达成共识.
主要成果:
- 在完全临床缓解的标准上达成共识:没有口服皮质类固醇,症状,恶化或发作,肺功能稳定.
- 在部分临床缓解方面也达成了共识:没有口服皮质类固醇,以及三项标准中的两项 (症状,恶化/发作,肺稳定性) 缺失.
- 德尔菲分析定义了一个有价值的,独立的工具,用于严重喘研究.
结论:
- 德尔菲方法成功地建立了严重喘缓解的共识定义.
- 定义的标准提供了一个标准化的方法来评估严重喘治疗的有效性.
- 这种工具对于SANI注册和未来的严重喘研究至关重要.
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