第一次多发性硬化症疾病调节疗法启动后11年的认知处理速度和身体残疾的轨迹
Elisa Longinetti1, Simon Englund2, Joachim Burman3
1Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden elisa.longinetti@ki.se.
Journal of neurology, neurosurgery, and psychiatry
|August 9, 2023
概括
在复发性复发性多发性硬化症 (RRMS) 中,在疾病调节疗法 (DMT) 开始后,处理速度保持稳定,但对一些人来说,身体残疾恶化. 在RRMS患者的认知功能和身体残疾进展之间存在着强烈的联系.
科学领域:
- 神经学 神经学
- 神经免疫学 神经免疫学
- 临床研究 临床研究
背景情况:
- 复发性缓解性多发性硬化症 (RRMS) 具有不可预测的神经系统缺陷的特征.
- 疾病调节疗法 (DMT) 的目的是改变疾病的过程和控制症状.
- 了解DMT对认知和身体功能的长期影响至关重要.
研究的目的:
- 确定RRMS患者在DMT启动后处理速度和身体残疾的不同轨迹.
- 调查与这些已识别的轨迹相关的预测因素.
- 探索随着时间的推移认知和身体功能变化之间的关系.
主要方法:
- 对多发性硬化症所有免疫疗法之间的比较 (COMIT) 队列的分析,这是瑞典全国性的观察性研究.
- 群组建模方法用于评估处理速度 (符号数字模式测试) 和身体残疾 (扩展残疾状态量表) 轨迹.
- 调查轨迹成员的预测因素,包括患者人口统计学,并发病症和初始的DMT类型.
主要成果:
- 确定了五个稳定的处理速度轨迹,从低得分到高得分.
- 观察到三个身体残疾轨迹:没有/稳定,最小/稳定,中度/严重的进展.
- 高龄,干扰素启动和并发症与较低的处理速度和更大的身体残疾有关.
结论:
- 在积极治疗的RRMS患者中,处理速度通常保持稳定.
- 患有中度身体残疾的患者表现出身体功能恶化的趋势.
- 在DMT启动后,处理速度轨迹和身体残疾进展之间发现了显著的关联.
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