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Updated: Jun 1, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

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高分辨率的RIG-I信号通路和抗病毒反应的动态表征

Sandy S Burkart1,2, Darius Schweinoch3, Jamie Frankish1,2

  • 1Research Group "Dynamics of Early Viral Infection and the Innate Antiviral Response", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center, Heidelberg, Germany.

Life science alliance
|August 9, 2023
PubMed
概括

这项研究揭示了RIG-I信号在抗病毒免疫中的精确动态. 我们开发了一个数学模型,以了解病毒RNA对RIG-I的激活如何导致抗病毒状态.

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Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells09:15

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Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...