预测术后炎症反应指标 胃癌胃切除术后传染性并发症
Ryohei Nishiguchi1, Takao Katsube1, Takeshi Shimakawa1
1Department of Surgery, Tokyo Women's Medical University Adachi Medical Center.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
|August 9, 2023
概括
胃癌患者的术后传染性并发症可以通过高C反应蛋白,白细胞计数和术后第三天的体温来预测. 高龄和吸烟史也表明这些并发症的风险增加.
科学领域:
- 在瘤学瘤学.
- 手术并发症 手术并发症
- 生物标志物 生物标志物
背景情况:
- 手术后传染性并发症 (PIC) 是胃癌手术的一个问题.
- 术后炎症反应指标 (PIRI),包括C反应蛋白 (CRP),体温 (BT) 和白细胞 (WBC) 计数,在临床上得到使用.
- 鉴定胃切除术后PIC的简单,实用的预测因子至关重要.
研究的目的:
- 在接受胃切除术的胃癌患者中研究PIC的预测因素.
- 为预测术后并发症建立一个简单而实用的指标.
- 评估PIRI和其他因素在PIC预测中的作用.
主要方法:
- 从200名患有I-III期胃癌的患者的临床数据的回顾性分析.
- 单变量和多变量分析以评估预测因素 (宿主,临床病理学,PIRI).
- 接收器操作特征 (ROC) 曲线分析,以确定预测因素的截止值.
主要成果:
- 确定了PIC的独立预测因素:年龄 (≥77岁),吸烟史,CRP水平 (≥14.8 mg/dL),白细胞计数 (≥116.0×10^2/μL) 和术后第3天的BT (≥37.4°C).
- 为每个显著预测因素建立了特定的截止值.
- 多变量分析证实了这些因素的统计学意义.
结论:
- 在术后第3天增加的CRP,白细胞计数和BT是胃癌中PIC的显著预测因素.
- 年龄和吸烟史也与增加PIC风险有关.
- 这些发现为在临床实践中预测PIC提供了一种简单而实用的方法.
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