[日本功能性食品的现状和问题:食品功能性的证据]
1Faculty of Regional Environment Science, Tokyo University of Agriculture.
概括
科学证据表明,日本的功能性食品声明系统存在重大质量问题. 系统性审查 (SR) 和临床试验 (CT) 都需要改进,以获得准确的消费者信息和购买决策.
科学领域:
- 食品科学 食品科学 食品科学
- 监管科学 监管科学
- 基于证据的医学 基于证据的医学
背景情况:
- 日本的功能性食品声明系统于2015年4月推出.
- 它的目的是为消费者提供有关食品功能的信息.
- 评估支持这些说法的科学证据对于消费者信任和知情选择至关重要.
研究的目的:
- 审查"功能性食品声明"系统中功能性的科学证据的现状.
- 识别和分析现有证据库中的问题和局限性.
- 为改善科学证据质量提供建议.
主要方法:
- 从2015年4月到2023年1月,向功能性食品声明系统提交的科学证据的叙述性审查.
- 分析了6606份通知,包括6297份系统性审查 (SR) 和309份临床试验 (CT).
- 使用PRISMA和AMSTAR检查清单评估SRs的方法质量,使用CONSORT2010检查清单评估CTs.
主要成果:
- 系统性审查 (SRs) 显示,基于PRISMA检查清单的报告不足,使用AMSTAR和AMSTAR 2的评估质量不佳.
- 临床试验 (CTs) 显示了协议和公布内容之间的不一致性 (不合规),存在高偏差风险,并且基于CONSORT 2010检查清单的报告不足.
- 发现很大一部分通知 (95.3%的SR,4.7%的CT) 存在质量问题.
结论:
- 提交给功能性食品声明系统的SR和CT都经常受到低方法质量的损害.
- 极其需要提高科学证据和报告标准的质量.
- 向消费者明确的证据质量沟通对于使功能性食品能够做出适当的购买决定至关重要.
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