人类测量和基于CT的肥胖指数与亚临床动脉样硬化症的关联
Yosuke Higo1, Takashi Hisamatsu2,3, Yoshihisa Nakagawa1
1Department of Cardiovascular Medicine, Shiga University of Medical Science.
Journal of atherosclerosis and thrombosis
|August 9, 2023
概括
在男性中,肥胖指数与冠状动脉化 (CAC) 和大动脉化 (AoAC) 有着不同的关联. 没有与大动脉膜化 (AVC) 相关的指数.
科学领域:
- 心血管疾病研究研究
- 肥胖医学 肥胖医学
- 医学成像分析 医学成像分析
背景情况:
- 亚临床动脉样硬化,包括冠状动脉结石化 (CAC),大动脉结石化 (AoAC) 和大动脉结石化 (AVC),是一个重大的健康问题.
- 各种肥胖指数与这些不同的化类型之间的关联的比较强度仍然不完全理解.
研究的目的:
- 为了比较基于人体测量和计算机断层扫描 (CT) 的肥胖指数与CAC,AoAC和AVC在基于人口的男性队列之间的关联的强度.
- 调查不同肥胖程度如何与亚临床动脉样硬化的具体表现有关.
主要方法:
- 在931名男性 (平均年龄63.7岁) 的横截面分析中,使用人体测量指标 (BMI,腰围等) 进行测量. 和CT衍生的脂肪组织指数 (VAT,SAT,VSR,VTR).
- 使用CT扫描中的Agatston分数来量化CAC,AoAC和AVC.
- 多变量回归模型根据年龄,生活方式因素和CT扫描仪类型进行调整.
主要成果:
- 在CAC和AoAC中占比较高 (分别为62.6%和82.6%).
- 人类测量和基于CT的肥胖指数都与CAC积极相关 (p<0.01).
- 内脏与皮下脂肪组织比率 (VSR) 和内脏与总脂肪组织比率 (VTR) 与AoAC积极相关 (p<0.01),但没有肥胖指数与AVC相关.
结论:
- 肥胖指数和亚临床动脉样硬化之间的关联因具体的解剖位置和化的类型而异.
- 内脏脂肪的测量特别与男人的大动脉化有关.
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