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在人类大脑中使用动态O-MRI在3T时量化区域CMRO₂

Hao Song¹, Johannes Fisher¹, Ali Caglar Özen¹

¹Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Zeitschrift fur medizinische Physik

|August 9, 2023

概括

动态17O-MRI可以在3T时测量大脑中氧气消耗 (CMRO2) 的区域大脑代谢率. 这种非侵入性方法揭示了健康志愿者的大脑氧化代谢的区域差异.

科学领域:

神经成像是一种神经成像.
生理学生理学生理学
医学物理医学物理

背景情况:

大脑代谢氧消耗率 (CMRO2) 是大脑组织健康的关键指标.
目前用于CMRO2测量的方法通常只提供全球大脑代谢数据.
需要区域CMRO2量化,以便详细了解局部大脑功能和新陈代谢.

研究的目的:

评估使用3Tesla (3T) MRI测量区域CMRO2的可行性.
在健康志愿者中,研究灰质 (GM) 和白质 (WM) 中CMRO2的区域变异.
为了比较3T MRI衍生的CMRO2值与现有的文献数据.

主要方法:

利用动态17O-MRI与吸入的17O气体来量化CMRO2.
测量区域CMRO2在正面,顶部和部的GM和WM.
在深层大脑结构 (大脑体,条状体,岛状体) 和小脑中确定CMRO2.

主要成果:

皮层GM CMRO2值与文献相一致;WM值高出32-48%.
尾部转基因显示的CMRO2显著高于前部和顶部转基因.
深层大脑结构具有较低的CMRO2;小脑显示出良好的半球对称性.

结论:

动态17O-MRI是一种可行的方法,用于在3T时非侵入性地确定区域CMRO2.
这项研究表明,有能力在大脑内区分区域代谢活动.
这些发现支持使用3T 17O-MRI进行详细的脑氧代谢评估.

关键词:

(17) O-MRI 的使用.大脑的氧化代谢氧化代谢大脑的氧气消耗代谢率 (CMRO(2))非质子核磁共振 (MRI) 是一种非质子核磁共振.对于CMRO的区域定量化(2)

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