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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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在糖尿病病患者中,阻塞性睡眠呼吸暂停,冠状动脉化和动脉硬
Sebastian Nielsen1, Jakob Nyvad1, Kent Lodberg Christensen2
1Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Atherosclerosis
|August 9, 2023
概括
糖尿病病患者的阻塞性睡眠呼吸暂停 (OSA) 与动脉硬度增加有关. 然而,中度至重度的OSA并不能独立预测这一群体的冠状动脉化.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 可能加速动脉化.
- 在糖尿病病 (DKD) 中,OSA和动脉健康之间的关系尚不清楚.
研究的目的:
- 为了研究OSA,冠状动脉化和大动脉硬性之间的关联,在患有DKD和功能下降的患者中.
主要方法:
- 患有2型糖尿病和降低EGFR/升高UACR的患者使用呼吸暂停-呼吸暂停指数 (AHI) 评估OSA.
- 冠状动脉化通过冠状动脉阿加特斯顿评分 (CAS) 量化,动脉硬性通过带-大腿脉冲波速率 (PWV) 量化.
- 在没有OSA的患者和中度至重度OSA的患者之间进行了比较.
主要成果:
- 与没有OSA的患者相比,OSA患者的CAS和PWV显著更高.
- 在多变量调整后,中度至重度的OSA仍然是PWV的重要预测因素.
- 确定OSA是影响PWV的关键因素,并且在较小程度上影响CAS.
结论:
- 在DKD患者中,中度至重度的OSA是动脉硬的重要预测因素.
- 在这组患者中,OSA与冠状动脉化没有独立的关联.
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