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一个HIF独立的氧气敏感通道用于控制胆固醇合成

Anna S Dickson1, Tekle Pauzaite1, Esther Arnaiz1,2

  • 1Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge, CB2 0AW, UK.

Nature communications
|August 9, 2023
PubMed
概括

胆固醇的合成依赖于氧气. 这项研究揭示了哺乳动物对氧气敏感的新途径,涉及醇调节元素结合蛋白2 (SREBP2) 的降解,这影响了癌细胞对胆固醇的依赖.

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