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在长时间太空飞行后,在宇航员身上进行骨髓脂肪化调节.

Tammy Liu1, Gerd Melkus2, Tim Ramsay3

  • 1Bone and Joint Research Laboratory, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8M2, Canada.

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太空飞行显著减少骨髓脂肪组织 (BMAT),这是一个关键的能量储备. 这种枯竭与返回地球后增加红细胞生产和骨生长有关.

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科学领域:

  • 太空医学 太空医学
  • 人体生理学 人体生理学
  • 骨生物学 骨生物学 骨生物学

背景情况:

  • 骨髓脂肪组织 (BMAT) 在骨和血液生产中起作用.
  • 太空旅行对BMAT的影响在很大程度上是未知的.
  • 了解BMAT调制对于宇航员在太空任务期间和之后的健康至关重要.

研究的目的:

  • 为了研究宇航员在太空飞行后骨髓脂肪组织 (BMAT) 的调节.
  • 探索BMAT变化,红色素形成和任务后的骨代谢之间的关系.
  • 假设BMAT作为骨髓能量来源的作用.

主要方法:

  • 14名宇航员在国际空间站六个月任务后的腰椎BMAT的分析.
  • 谱分析以评估骨髓脂肪储量.
  • 在BMAT水平,红色素形成和骨代谢之间进行时间相关性分析.

主要成果:

  • 在太空飞行后41天观察到腰椎BMAT显著下调.
  • 频谱分析表明,骨髓脂肪储量的耗尽.
  • 增强的红色受体和骨代谢暂时与飞行后的BMAT降低有关.

结论:

  • BMAT 作为高代谢性骨髓飞行后的优先局部能量来源,导致其下调.
  • 晚期飞行后BMAT上调被注意到,特别是在女性宇航员中.
  • 年龄影响了BMAT调制幅度,年轻的宇航员表现出更大的变化.