在日本人口中,脂肪酸摄入量与糖尿病视网膜病变之间的关联
Mariko Sasaki1,2, Kenya Yuki3, Akiko Hanyuda3
1Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. marii.kt@gmail.com.
Scientific reports
|August 9, 2023
概括
总脂肪和和脂肪酸 (SFA) 的高摄入量与日本成年人糖尿病视网膜病变 (DR) 有关. 这一发现表明,饮食脂肪可能会影响DR的发展,即使总体脂肪消耗较低.
科学领域:
- 眼科医生 眼科 眼科
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病患者视力丧失的主要原因.
- 饮食因素,包括脂肪酸摄入量,可能会影响DR的发展和进展.
- 了解特定的饮食成分与DR之间的关系对于预防策略至关重要.
研究的目的:
- 调查饮食脂肪酸摄入量与日本人口中糖尿病视网膜病变 (DR) 的患病率之间的关联.
- 为了确定特定类型的脂肪酸 (总脂肪,和脂肪,单不和脂肪,不和脂肪) 是否与糖尿病患者的DR有关.
主要方法:
- 在 Chikusei 市,对647名年龄在40-74岁之间的糖尿病患者进行了横截面研究.
- 通过使用食物频率问卷来评估饮食摄入量,脂肪酸摄入量以总能量的百分比计算.
- 糖尿病视网膜病变 (DR) 的诊断是基于早期治疗糖尿病视网膜病变研究 (ETDRS) 标准 (两只眼睛的水平≥20).
主要成果:
- 在647名参与者中,有100人患有DR. 平均总脂肪和和脂肪酸 (SFA) 摄入量分别为总能量的22.0%和7.3%.
- 较高的总脂肪和SFA摄入量的四分位数与较低的四分位数相比,与DR的概率增加显著相关 (分别为OR2.61和2.40),经过对混因素进行调整后.
- 在DR流行率和单不和或不和脂肪酸摄入量之间没有发现显著的关联.
结论:
- 高摄入总脂肪和SFA可能与患糖尿病视网膜病变 (DR) 的风险增加有关.
- 这些发现凸显了食脂肪,特别是SFA在DR病原体中的潜在作用,即使在一般脂肪消耗较低的人群中也是如此.
- 需要进一步的研究,以阐明连接食脂肪酸与DR的机制,并为糖尿病管理的饮食指南提供信息.
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