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血清叶酸与非酒精性脂肪肝疾病和晚期肝纤维化有关

Hao-Kai Chen^1,2, Jing Luo^1,2, Xiu-Juan Li^1,2

¹Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Scientific reports

|August 9, 2023

概括

高血清叶酸水平与美国成年人非酒精性脂肪性肝病 (NAFLD) 和晚期肝纤维化 (AHF) 的几率降低有关. 这表明叶酸可能在预防肝病进展方面起着保护作用.

科学领域:

肝病学肝病学是一种肝病学.
营养科学营养科学
公共卫生公共卫生

背景情况:

血清叶酸与非酒精性脂肪性肝病 (NAFLD) 之间的关系受到争论.
全球范围内,NAFLD影响了相当一部分成年人口.
晚期肝纤维化 (AHF) 是NAFLD的一个严重并发症.

研究的目的:

检查血清叶酸水平与NAFLD流行率之间的关联.
调查血清叶酸水平与AHF之间的关联.

主要方法:

这是一项横截面研究,利用了2011-2018年国家健康和营养检查调查 (NHANES) 中的5417名参与者的数据.
统计分析包括多重逻辑回归和倾向得分匹配.
为了进行比较,参与者被分为低血清叶酸和高血清叶酸组.

主要成果:

在完全调整后,较高的血清叶酸水平与较低的NAFLD (OR 0.73,95% CI 0.62-0.87) 和AHF (OR 0.47,95% CI 0.35-0.63) 的几率显著相关.
倾向性得分匹配分析证实了这些关联.
分层分析表明,不同人口子组之间存在一致的负相关性.

结论:

血清叶酸水平升高与美国成年人中NAFLD和AHF的可能性降低有关.
这些发现表明叶酸在肝病中可能起着保护作用.
鉴于本研究的横截面性质,需要进一步的前性研究来确定因果关系.

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