短暂的呼吸暂停和周期性呼吸在早产婴儿的发育后果
Alicia K Yee1, Leon S Siriwardhana1, Gillian M Nixson1,2
1Department of Paediatrics, Monash University, Melbourne, VIC, Australia.
概括
早产婴儿在出院前发生的呼吸系统事件会影响后来的发育. 预测到期的呼吸事件的时间增加,预测到6个月后的较低语言和运动分数,经过年龄校正.
科学领域:
- 新生儿发育的新生儿发展
- 婴儿呼吸系统生理学 婴儿呼吸系统生理学
背景情况:
- 过早出生的婴儿往往会经历呼吸系统事件.
- 了解这些事件的长期影响对于发展结果至关重要.
研究的目的:
- 调查早产婴儿呼吸事件与发育结果之间的关联.
- 为了确定6个月的发育结果的预测因素,校正年龄.
主要方法:
- 在多个时间点研究过早产婴儿 (28-32周妊娠年龄).
- 计算的百分比总睡眠时间 (%TST) 与呼吸系统事件 (呼吸暂停,周期性呼吸).
- 使用逐步的多重线性回归来识别重要的预测因素.
主要成果:
- 术后有呼吸道事件的%TST是语言和运动分数的重要预测因素.
- 较高的TST%与呼吸系统事件与贝利婴儿发育量表上的较低复合分数相关.
- 这些发现独立于妊娠年龄,出生体重和性别.
结论:
- 在稳定的非常早产婴儿中,在术语相当的年龄度度过呼吸事件的时间与在6个月的校正年龄下减少的语言和运动结果有关.
- 早期呼吸事件管理对于优化神经发育轨迹可能很重要.
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