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Updated: Jul 19, 2025

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A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
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在轻度COVID-19后的嗅觉功能障碍中改变了结构连接性,使用概率曲谱学
Diógenes Diego de Carvalho Bispo1,2,3, Pedro Renato de Paula Brandão4,5, Danilo Assis Pereira6
1Diagnostic Imaging Unit, Brasilia University Hospital, University of Brasilia, Darcy Ribeiro Campus, Asa Norte, Brasilia, Distrito Federal, Brazil. dbispo.neurorradio@gmail.com.
Scientific reports
|August 9, 2023
概括
在COVID-19后持续的嗅觉功能障碍与减少的嗅觉球体体积和改变的白质脑网络有关. 这些变化表明嗅觉恢复的潜在补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 传染性疾病 传染性疾病
背景情况:
- 持续的嗅觉功能障碍 (OD) 是COVID-19的常见后果.
- 基础的神经变化,特别是白质 (WM) 大脑网络,仍然不完全理解.
研究的目的:
- 研究COVID-19后持久性OD患者嗅球体积和WM大脑网络的变化.
- 探索结构性大脑网络变化与嗅觉功能缺陷之间的关系.
主要方法:
- 对38名OD和24名对照COVID-19患者的横截面研究.
- 使用了嗅探棒识别测试 (SS-16),MoCA和大脑MRI.
- 雇员基于网络的统计 (NBS) 和图形理论分析用于WM网络探索.
主要成果:
- 与对照组相比,COVID-19组的嗅觉球体体积减少.
- 在COVID-19患者中观察到 parietal 脑区的结构连接性增加.
- 患者表现出较低的全球/本地效率,更高的分类性,以及改变的本地网络属性,包括效率降低和在特定地区增加集群.
结论:
- 患有COVID-19后OD的患者表现出显著的WM网络功能障碍.
- 增加的状连接和改变的网络拓表明了补偿性可塑性机制.
- 这些发现突显了COVID-19对嗅觉通路的神经影响.
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