在小儿肥胖症中考虑脏问题
Alexandra Sawyer1, Evan Zeitler2, Howard Trachtman3
1Department of Pediatrics, Division of Endocrinology, University of Colorado School of Medicine, 13123 East 16Th Avenue, Box 158, Aurora, CO, 80045, USA. Alexandra.sawyer@childrenscolorado.org.
Current obesity reports
|August 9, 2023
概括
与肥胖相关的脏疾病和糖尿病脏疾病会影响儿童,可能导致晚年慢性脏疾病. 在儿科患者中早期发现损伤对于干预至关重要.
科学领域:
- 儿科脏病学 儿科脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 对成年人构成重大风险,儿童和青少年也容易受到早期损伤的影响.
- 肥胖是通过直接和间接途径促进CKD发展的关键因素.
- 了解儿科病对于长期健康结果至关重要.
研究的目的:
- 在儿童群体中审查与肥胖相关的病 (ORKD) 和糖尿病病 (DKD).
- 描述ORKD和DKD对儿童和青少年的影响.
- 强调早期检测和干预的重要性.
主要方法:
- 小儿肥胖和脏疾病的文献综述.
- 早期损伤表型的分析.
- 检查新兴的治疗策略.
主要成果:
- 与肥胖相关的CKD在儿科患者中不常见,但会增加终身CKD风险.
- 淋巴细胞过是ORKD和DKD的早期指标,前面是白蛋白尿和GFR下降.
- 儿童肥胖和2型糖尿病的新疗法正在研究中,具有脏保护作用.
结论:
- 儿童肥胖和糖尿病的早期损伤可能会产生持久的后果.
- 识别诸如球过等早期症状是及时干预的关键.
- 需要进一步的研究,以充分理解和管理儿科患者的病.
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