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Updated: Jul 19, 2025

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
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Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Published on: July 23, 2016

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基于生理学的转化性药理动力学模型用于单克隆抗体的眼部处置

Sanika Naware1, David Bussing1, Dhaval K Shah2

  • 1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York, University at Buffalo 455 Kapoor Hall, Buffalo, NY, 14214-8033, USA.

Journal of pharmacokinetics and pharmacodynamics
|August 9, 2023
PubMed
概括

这项研究适应了子对单克隆抗体 (mAbs) 的药理动力学模型,用于非人类灵长类动物 (NHP) 和人类. 该模型准确地预测了眼睛组织中的mAb配置,有助于开发用于眼睛疾病的新抗体疗法.

关键词:
抗体是对抗体的一种.眼睛 眼睛 眼睛 眼睛人类 人类 人类 人类 人类一个子子.眼睛的药理动力学 眼睛的药理动力学基于生理学的药理动力学模型

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