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Updated: Jul 19, 2025

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在NDUFC2的多态变异,编码线粒体综合体I子单元,与人类高血压中的心脏缩有关

Giovanna Gallo1, Maurizio Forte2, Maria Cotugno2

  • 1Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy.

Molecular medicine (Cambridge, Mass.)
|August 9, 2023
PubMed
概括

NDUFC2中的遗传变异与高血压患者的左心室缩 (LVH) 有关. 缺乏NDUFC2会损害线粒体功能,增加对心脏缩的易感性.

关键词:
心脏过度缩小的心脏过度缩小在高血压的高血压.线粒体复合体I 线粒体复合体I线粒体功能障碍 线粒体功能障碍这就是NDUFC2的原因.在SIRT3中,SIRT3是最重要的.

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