基于临床因素和生化血液标志物,用于预测急性隔间综合征患者的截肢率的实用名录
Donglei Wei1,2, Jianwen Cheng1,2, Yage Jiang3
1Department of Traumatology and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, China.
BMC musculoskeletal disorders
|August 9, 2023
概括
现在,外科医生可以更好地预测急性隔间综合征 (ACS) 患者的截肢风险,使用新的名谱. 该工具分析受伤原因,血管损伤,冲击和纤维素素水平,以改善肢体保护策略.
科学领域:
- 整形外科手术 整形外科手术
- 创伤管理 创伤管理
- 血管外科 血管外科
背景情况:
- 截肢是急性隔间综合征 (ACS) 的严重并发症.
- 在ACS患者中预测截肢风险对临床医生来说是一个重大挑战.
- 准确的风险分层对于及时干预和肢体救援至关重要.
研究的目的:
- 确定ACS患者截肢的主要危险因素.
- 开发和验证ACS中截肢风险的预测名录.
- 增强ACS.中的肢体保存的临床决策.
主要方法:
- 一项对143名ACS患者 (32名截肢,111名肢体保存) 的回顾性研究.
- 使用LASSO和多变量逻辑回归来进行预测器选择.
- 使用ROC曲线,C指数,校准图表和DCA评估的诺米克图表性能.
主要成果:
- 确定了关键预测因素:受伤原因,血管损伤,冲击和纤维素水平.
- 诺米图实现了0.872的C指数 (内部验证:0.838) 和0.849.84的AUC.
- 校准曲线和DCA证实了良好的预测准确性和临床效用.
结论:
- 在ACS中截肢的风险受到损伤原因,血管损伤,冲击和纤维素因子的显著影响.
- 开发的诺米图有效地整合了临床和生化因素,以便方便地预测截肢风险.
- 该工具有助于临床医生优化ACS患者的治疗策略,旨在降低截肢率.
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