支臂疗法用于向宫癌患者的免疫系统
Isabel Linares1,2, Miguel Ángel Berenguer Frances3, Rut Cañas4
1Radiation Oncology Department, Hospital Duran i Reynals, Institut Català d'Oncologia (ICO), Avinguda de la Gran Via de l'Hospitalet 199-203, L'Hospitalet de Llobregat, 08098, Barcelona, Spain. ilinaresgaliana@iconcologia.net.
BMC immunology
|August 9, 2023
概括
在宫癌患者中,高剂量速率支臂治疗 (HDR-BT) 增强了细胞毒性自然杀手 (NK) 细胞,比脉冲剂量速率支臂治疗 (PDR-BT) 更有效. 这表明HDR-BT可能在免疫疗法组合中优越.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 辐射疗法 辐射疗法
背景情况:
- 了解传统癌症治疗的免疫调节作用对于新的治疗组合至关重要.
- 支臂疗法 (BT) 是宫癌的标准治疗方法,但它对免疫系统的影响需要进一步调查.
- 将高剂量速率支臂治疗 (HDR-BT) 和脉冲剂量速率支臂治疗 (PDR-BT) 进行比较对于确定免疫调节的最佳模式至关重要.
研究的目的:
- 评估支臂治疗对宫癌患者免疫系统的影响.
- 为了比较HDR-BT与PDR-BT的免疫调节作用.
- 识别潜在的生物标志物来预测治疗反应和指导免疫疗法组合.
主要方法:
- 一项前性研究,涉及19名宫癌患者,接受化学辐射 (CRT) 治疗,随后进行HDR-BT或PDR-BT.
- 在多个时间点采集了周围血液样本以通过流细胞计进行免疫型定型.
- 统计分析包括弗里德曼单向ANOVA,康诺弗后期测试和威尔科克森签名等级测试,以比较细胞群变化.
主要成果:
- 高剂量速率支架疗法 (HDR-BT) 与脉冲剂量速率支架疗法 (PDR-BT) 相比,显著增加了具有更高细胞毒性能力的CD56dimCD16+自然杀手 (NK) 细胞.
- PDR-BT导致CD56-CD16+NK细胞的增加.
- 这两种BT疗法都增加了骨髓衍生抑制细胞 (MDSC),与更差的预后相关,而HDR-BT显示了对调节性T细胞 (Tregs) 减少的趋势.
结论:
- 自然杀手 (NK) 细胞是宫癌中手臂治疗的关键目标.
- 与PDR-BT相比,HDR-BT表现出更有利的免疫调节特征,其特征是较高的细胞毒性NK细胞和Tregs潜在减少,与PDR-BT相比.
- 这些发现支持将HDR-BT与免疫疗法结合使用,以改善宫癌治疗结果.
更多相关视频
相关概念视频
Tumor Immunotherapy
557
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
557
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Vaccines
403
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
403
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Cell-mediated Immune Responses
68.9K
Overview
68.9K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K


