在COVID-19疫苗接种后,疹病毒的重新激活:系统性审查和元分析
Arman Shafiee1,2, Mohammad Javad Amini2, Razman Arabzadeh Bahri3
1Clinical Research Development Unit, Alborz University of Medical Sciences, Karaj, Iran.
European journal of medical research
|August 9, 2023
概括
接种COVID-19疫苗可能与疹病毒的重新激活有关,特别是疹病毒 (VZV) 和简单疹病毒 (HSV). 对爱斯坦-巴尔病毒 (EBV) 和细胞巨核病毒 (CMV) 需要进一步的研究.
科学领域:
- 病毒学和免疫学 病毒学和免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 在COVID-19患者中记录了人类疹病毒 (HHV) 的重新激活.
- 报告显示,在COVID-19疫苗接种后,HHV重新激活.
- 现有的文献表明,HHV重新激活和COVID-19疫苗之间存在潜在联系.
研究的目的:
- 系统地审查和评估COVID-19疫苗接种和HHV重新激活之间的关联.
- 评估目前的证据,以确定之前的COVID-19疫苗是否会触发HHV的重新激活.
主要方法:
- 2022年9月25日,在PubMed/MEDLINE,Web of Science和EMBASE进行了系统的文献搜索.
- 包括的研究包括观察性研究,病例报告和病例系列,详细介绍COVID-19疫苗接种后的HHV再激活.
- 进行了一项比例的元分析,以量化VZV和HSV重新激活率.
主要成果:
- 80篇文章符合纳入标准;大多数评估的COVID-19疫苗都是基于mRNA的.
- 观察性研究表明,COVID-19疫苗与VZV (14/1000次疫苗接种) 和HSV (16/1000次疫苗接种) 重新激活之间存在潜在联系.
- 病例报告/病例系列记录了149例HHV再激活病例,其中VZV (n=114) 和HSV (n=14) 是最常见的,通常是在第一剂疫苗后和患有并发症的患者中.
结论:
- 这项研究表明,COVID-19疫苗接种与疹病毒重新激活之间可能存在关联,特别是VZV和HSV.
- 支持VZV和HSV重新激活的证据得到了观察性研究的加强.
- 需要进一步的研究,包括临床试验,以澄清COVID-19疫苗接种和EBV/CMV重新激活之间的关系.
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