循环瘤DNA的改变:新兴的生物标志物在头部和部状细胞癌
Xiaomin Huang1, Pascal H G Duijf2,3,4,5,6,7, Sharath Sriram8
1Saliva and Liquid Biopsy Translational Laboratory, Griffith Institute for Drug Discovery (GRIDD), School of Environment and Science, Griffith University, QLD, Brisbane, Australia.
Journal of biomedical science
|August 9, 2023
概括
使用循环瘤DNA (ctDNA) 的液体活检为头部和部状细胞癌 (HNSCC) 管理提供了一种最小侵入性的方法. 这种方法有助于预后和疾病监测,为个性化医疗和改善患者结果铺平了道路.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
背景情况:
- 头部和部癌症 (HNC),主要是头部和部状细胞癌 (HNSCC),占全球健康的重大负担.
- 目前HNSCC的诊断和治疗计划在很大程度上依赖于传统的组织病理学,由于瘤异质性和解剖学可访问性而面临挑战.
研究的目的:
- 审查循环瘤DNA (ctDNA) 作为头部和部状细胞癌 (HNSCC) 管理的有前途的生物标志物的作用.
- 讨论ctDNA在克服HNSCC患者传统组织活检局限性的潜力.
主要方法:
- 专注于ctDNA作为HNSCC中的液体活检生物标志物.
- 审查ctDNA释放的机制,ctDNA分析的技术进步及其在HNSCC中的应用.
- 讨论ctDNA临床翻译的挑战和未来前景.
主要成果:
- ctDNA为HNSCC的组织活检提供了一个强大的,最少侵入性的替代方案.
- 液体活检方法,特别是ctDNA分析,可以解决瘤异质性和可访问性问题.
- ctDNA有助于重复采样,这对于监测疾病进展和治疗反应至关重要.
结论:
- ctDNA是HNSCC预后和疾病监测的宝贵生物标志物.
- 对ctDNA分析的临床整合有望在HNSCC中推进个性化医疗.
- 在HNSCC管理中,ctDNA有可能显著改善患者的治疗结果,并降低医疗保健成本.
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