作为视觉空间功能障碍的预测因子,左前骨的增强活动与类风湿性关节炎的疾病活动相关
Yanmin Zheng1,2, Lei Xie1,2, Zikai Huang1,2
1Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, No. 57 ChangPing Road, Shantou, 515041, Guangdong, China.
European journal of medical research
|August 9, 2023
概括
类风湿性关节炎 (RA) 患者表现出大脑活动的改变,特别是在左前,影响视觉空间功能. 这种神经变化与疾病活动相关,可以作为诊断生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 类风湿性关节炎 (RA) 是一种全身性自身免疫性疾病.
- 视觉空间功能障碍在RA患者中越来越被认可.
- 神经成像生物标志物是早期诊断和监测RA所需的.
研究的目的:
- 为了确定RA的潜在诊断生物标志物.
- 评估RA患者视觉空间功能与疾病活性之间的关系.
- 在此评估中使用基于心理旋转任务 (MRT) 的功能磁共振成像 (fMRI).
主要方法:
- 27名RA患者 (11例缓解,16例活跃) 和27名对照患者在MRT期间接受了fMRI.
- 使用MRT性能来评估视觉空间功能.
- 疾病活动被用疾病活动评分28 (DAS28) 来衡量.
主要成果:
- 与对照组相比,RA患者的MRT表现较差,大脑激活模式发生变化.
- 在RA患者中观察到左前,左上额头,右带带状的增强激活.
- 左前关节激活与DAS28正相关,与MRT精度负相关,这表明神经变化,视觉空间缺陷和疾病严重程度之间存在联系.
结论:
- 在RA患者中,左前肌激活的增强与视觉空间功能受损有关.
- 这种神经变化与RA疾病活动密切相关.
- 这些发现表明,基于fMRI对左前骨的评估可能是RA的神经成像生物标志物.
相关概念视频
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...


