在长期太空任务期间,用于肌肉骨系统的辅助药理策略
Friederike Thomasius1, Dominik Pesta2,3,4, Jörn Rittweger2,5
1Frankfurter Hormon & Osteoporosezentrum, Frankfurt, Germany.
British journal of clinical pharmacology
|August 9, 2023
概括
太空旅行导致肌肉消耗和骨质损失,尽管运动. 可注射的骨质再吸收抑制剂和潜在的类固醇可能提供解决方案,建议为宇航员肌肉骨健康采取联合炼和药物治疗方法.
科学领域:
- 太空医学 太空医学
- 肌肉骨生理学 肌肉骨生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 宇航员在太空任务期间经历了显著的肌肉消耗和骨损失,即使每天炼.
- 骨损失率的个体变化需要改善长期太空飞行对策.
- 目前的炼方案不足以完全缓解太空飞行引起的肌肉骨衰竭.
研究的目的:
- 审查目前用于预防宇航员肌肉消耗和骨损失的药理策略.
- 评估双酸盐,RANKL抗剂和硬质素抗剂在太空旅行中的有效性和安全性.
- 探索类固醇和联合对策的潜力,在太空任务期间保持肌肉骨健康.
主要方法:
- 对药理学药物和炼干预措施的现有文献的审查,用于骨质损失和肌肉消耗.
- 对双酸盐 (阿伦德罗酸盐,佐勒德罗酸盐),登苏马布和罗莫苏马布对骨再吸收的影响进行分析.
- 对类固醇对肌肉蛋白质合成及其与运动刺激的相互作用的评估.
主要成果:
- 像阿伦德罗纳特这样的口服双酸盐显示出有效性,但有胃肠道副作用.
- 可以注射的药物 (zoledronate,denosumab,romosozumab) 有效抑制骨吸收,是可行的选择,在短期使用时很少出现严重的副作用.
- 类固醇对肌肉消耗的有效性有限,需要与力量训练相结合.
结论:
- 可以注射的抗吸收药物可能对高骨吸收率的宇航员有益,超过短期任务的风险.
- 建议在太空旅行到月球和火星期间采取运动和药理学对策的综合方法,以保持肌肉骨健康.
- 为了全面维护宇航员的健康,需要对合成代谢剂和优化的运动方案进行进一步的研究.
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