基底和中大脑运动区域连接矩阵
Nicolás A Morgenstern1,2, Maria S Esposito3
1Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal.
Current neuropharmacology
|August 10, 2023
概括
中大脑运动区 (MLR) 和基底腺 (BG) 之间有着复杂的联系,这挑战了将MLR视为简单的中继器的观点. MLR子电路向BG发送特定的电机和非电机信息,积极调整行为.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 基底性 Ganglia 研究 研究
背景情况:
- 中大脑运动区 (MLR) 传统上被视为基底腺 (BG) 输出的中继站.
- 最近的研究揭示了MLR和BG之间的复杂,相互关系.
研究的目的:
- 审查过去十年关于MLR和BG的相互联系的文献.
- 提出对MLR在运动控制和行为中的作用的修订理解.
主要方法:
- 评论最近的科学文献.
- 分析使用基于病毒的追踪,光遗传学和神经映射技术的研究.
主要成果:
- 该MLR包含多种神经元类型 (胆固醇,谷氨酸,GABAergic) 和项目上升纤维到BG.
- MLR投影传递运动和非运动信息给特定的BG核.
- 独特的MLR子区域和神经元子群形成独立的电路,影响特定的行为 (运动,姿势,强化).
结论:
- MLR不是一个均的输出结构,而是包含多个独立的子电路.
- 这些MLR子电路积极为BG提供上升信息,影响行为执行和调整.
- 经典的MLR-BG相互作用模型需要修订,以纳入这些发现.
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