1型糖尿病青少年的心血管风险因素:患病率和性别差异
Doğuş Vurallı1, Lala Jalilova2, Ayfer Alikaşifoğlu1
1Hacettepe University Faculty of Medicine, Department of Pediatrics, Clinic of Pediatric Endocrinology, Ankara, Turkey
Journal of clinical research in pediatric endocrinology
|August 10, 2023
概括
患有1型糖尿病 (T1D) 的女孩因肥胖和相关因素而面临更高的心血管疾病 (CVD) 风险. 早期干预对于这些年轻女性来说至关重要,以减轻这些风险.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 心血管疾病 (CVD) 是1型糖尿病 (T1D) 死亡的主要原因.
- 超重和肥胖在患有T1D的儿童中越来越普遍,反映或超过一般儿科人口的比率.
- 了解这一脆弱群体中心血管疾病风险因素对于有效管理至关重要.
研究的目的:
- 确定患有T1D的儿童和青少年心血管疾病风险因素的患病率.
- 分析肥胖和性别差异对这些心血管风险因素的影响.
主要方法:
- 评估来自365名T1D患者 (10-21岁) 的数据,这些患者至少接受了三年强化胰岛素治疗.
- 根据BMI百分位,将患者分为正常体重 (NW),超重 (OW) 和肥胖 (Ob) 组.
- 体重组和性别之间的心血管疾病风险因素 (肥胖,脂质失调,高血压) 的比较.
主要成果:
- 肥胖的发病率在女孩 (30.6%) 比男孩 (20.1%) 高.
- 超重/肥胖的女孩表现出高血压,LDL胆固醇和甘油三水平升高的最高率.
- 与男孩相比,患有T1D的女孩患有两种或多种心血管疾病风险因素的可能性是男孩的1.9倍.
结论:
- 与男孩相比,患有T1D的女孩,特别是那些超重或肥胖的女孩,对心血管疾病风险因素的趋势更大.
- 这些发现强调了T1D女孩对心血管风险的脆弱性增加,需要有针对性的早期干预.
- 需要进一步的研究,以了解T1D青少年心血管疾病风险的这些基于性别的差异的潜在原因.
相关概念视频
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Diabetes: Symptoms, Diagnosis, and Complications
590
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
590
Pathophysiology of Diabetes
989
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
989
Carbohydrate Metabolism
11.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.2K


