冷藏的多剂量胰岛素瓶在使用6个月后仍然是无菌的
A S Berg1, M E Jacob1, L B Mamo1
1North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
The Journal of small animal practice
|August 10, 2023
概括
冷藏的多剂量胰岛素小瓶在6个月的常规使用中保持无菌. 这项研究发现,即使没有酒精拭子制备,胰岛素格拉金和原胺胰岛素的感染风险最小.
科学领域:
- 微生物学 微生物学
- 制药科学 制药科学
- 传染性疾病 传染性疾病
背景情况:
- 多剂量胰岛素瓶通常用于糖尿病管理.
- 有关重复使用胰岛素瓶的微生物污染存在担忧.
- 和甲醇等防腐剂包括在胰岛素配方中,以抑制微生物生长.
研究的目的:
- 为了评估冷藏的多剂量胰岛素小瓶在六个月的常规吸收期间的无菌性.
- 评估酒精抹布制备对瓶子无菌性的影响.
主要方法:
- 十二个多剂量胰岛素瓶 (六个胰岛素glargine U100,六个蛋白质氨基胰岛素U40) 被冷藏,并在六个月内每天吸入两次.
- 吸入样本进行培养,以检测微生物生长.
- 在吸入前,每种类型的三个瓶子都被涂抹了酒精;其他没有.
主要成果:
- 在整个六个月的研究中,在任何瓶子中都没有发现微生物污染.
- 一个瓶子显示了Staphylococcus epidermidis的不可重复的生长.
- 总共培养了454个样本.
结论:
- 冰箱中的多剂量胰岛素产品含有或甲醇防腐剂,在长达六个月的时间内,具有较小的阳性感染风险.
- 在吸入前的酒精抹布制备在本研究中没有显著影响瓶子无菌性.
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