萨尔科佩尼亚的一年变化与血液透析患者的认知障碍有关
Yuqi Yang1, Jingjing Da1, Jing Yuan1
1Department of Nephrology, Guizhou Provincial People's Hospital, Guiyang, China.
Journal of cachexia, sarcopenia and muscle
|August 10, 2023
概括
在血液透析患者中,新发性或持续性萨科佩尼亚与认知能力下降,轻度认知障碍和痴呆症有关. 早期发现和干预对于改善这一群体的认知健康至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年病的医生 老年病的医生
- 神经学 神经学
背景情况:
- 麻症和认知障碍在血液透析 (HD) 患者中很常见.
- 沙科佩尼亚进展和HD患者的认知衰退之间的纵向关系仍未得到充分研究.
研究的目的:
- 为了评估在1年内在HD患者中,sarcopenia及其组成部分的变化.
- 调查萨科佩尼亚变化与认知能力下降,发生轻度认知障碍 (MCI) 和痴呆症的关联.
主要方法:
- 这是一项多中心的纵向研究,在中国对1117名患有HD的患者进行.
- 根据亚洲 Sarcopenia 工作组的标准 (尾骨肌肉质量指数[ASMI]和手握强度[HGS]) 诊断出 Sarcopenia.
- 使用迷你精神状态检查评估认知功能;用于检查关联的多变量回归分析.
主要成果:
- 37.1%的患者在基线时患有肉类;23%的患者在随访期间患有MCI和12.8%的患者患有痴呆症.
- 患有新发性或持续性肉症的患者显示MCI和痴呆症的风险明显更高.
- 麻症和HGS/ASMI衰退与更快的认知衰退有关;具体关联因子组而异.
结论:
- 新发性和持续性皮症在长度上与HD患者的认知障碍有关.
- 针对肉症的干预措施可能有助于改善这一群体的认知健康.
- 建议在HD患者中早期检测和治疗肉类症.
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