内脏脂肪对冠状动脉疾病的影响,以定量计算断层扫描血管学定义
Daniel Karlsberg1,2,3, Henry Steyer4, Rebecca Fisher5
1The Princeton Longevity Center, New York, New York, USA.
Obesity (Silver Spring, Md.)
|August 10, 2023
概括
增加的内脏脂肪 (VF) 与更多的冠状动脉斑块相关,包括高风险的低密度非化斑块 (LD-NCP). 这表明VF可能有助于预测心血管疾病 (CVD) 风险.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
- 肥胖医学 肥胖医学
背景情况:
- 肥胖是所有原因死亡率和心血管疾病 (CVD) 的重要危险因素.
- 内脏脂肪 (VF) 是心血管疾病风险的关键指标,与心肌梗塞和中风独立相关.
- 了解VF和冠状动脉斑块之间的关系对于心血管疾病风险分层至关重要.
研究的目的:
- 调查内脏脂肪 (VF) 的存在和严重程度之间的关联.
- 为了确定VF与冠状动脉斑块的存在和程度之间的关系.
- 探索VF与特定类型的冠状动脉斑块之间的相关性,包括低密度非化斑块 (LD-NCP).
主要方法:
- 145名无症状患者接受了动脉样硬化成像定量计算断层扫描 (AI-QCT).
- AI-QCT评估了总斑块体积 (TPV),非化斑块 (NCP),化斑块,LD-NCP和狭窄.
- 量化了内脏脂肪 (VF) 和皮下脂肪体积,腰围和身体脂肪百分比.
主要成果:
- 在VF和TPV (r=0.22,p=0.0074),NCP (r=0.25,p=0.0023) 和LD-NCP (r=0.37,p<0.0001) 之间发现了显著的正相关性.
- 冠状动脉斑块体积,包括TPV,NCP和LD-NCP,在VF四分位数中逐渐增加.
- 较高的VF水平与高风险斑块类型LD-NCP的增加量密切相关.
结论:
- 增加的内脏脂肪 (VF) 与更大的冠状动脉斑块负担有关,包括TPV,NCP和LD-NCP.
- VF和LD-NCP之间的强烈关联凸显了VF在识别未来心血管事件高风险个体方面的潜在作用.
- 内脏脂肪 (VF) 可能成为心血管疾病 (CVD) 风险分层的宝贵工具.
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