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Updated: Jul 19, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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在TP53中变异性等位基因频率的变化预测了转移性尿路细胞癌患者的pembrolizumab反应

Kazuki Hamada1, Yoshiyuki Nagumo1, Shuya Kandori1

  • 1Department of Urology, Faculty of Medicine and Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

Oncology letters
|August 10, 2023
PubMed
概括

血循环瘤DNA (ctDNA) 分析,特别是TP53突变,可以预测转移性尿路细胞癌 (mUC) 中对 pembrolizumab 的反应. 这种非侵入性生物标志物有助于监测mUC患者的治疗有效性.

关键词:
这就是TP53的特点.在循环中的瘤DNA.基因组的改变是基因组的改变.免疫检查点抑制剂免疫检查点抑制剂响应 响应 响应 响应

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