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使用综合生物信息学分析识别ATP6V0A4作为细胞癌的潜在生物标志物

Jinming Xu^1,2, Jiahao Jiang³, Cong Yin¹

¹Department of Urology, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518035, P.R. China.

Oncology letters

|August 10, 2023

概括

这项研究确定ATP6V0A4是清细胞细胞癌 (ccRCC) 的潜在生物标志物. 低ATP6V0A4表达与ccRCC患者的预后不佳和复发有关,这表明它是治疗目标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

清细胞细胞癌 (ccRCC) 是最常见的癌类型,其特点是由于复发和转移导致的高死亡率.
识别特定的分子生物标志物对于改善ccRCC诊断和治疗策略至关重要.

研究的目的:

确定清细胞细胞癌 (ccRCC) 的特定和敏感的分子生物标志物.
研究已识别的生物标志物在ccRCC进展和患者预后中的作用.

主要方法:

对八个ccRCC基因表达全集数据集的综合生物信息学分析,以识别差异表达基因 (DEG).
使用逆转录定量PCR (RT-qPCR),西部抹杀和免疫组织化学对255ccRCC和165个正常脏样本进行候选生物标志物的验证.
利用癌症基因组图谱 (TCGA) 数据库进行进一步的验证和生存分析.

主要成果:

确定了344种重要的DEG (115种上调,229种下调) 在"有机离子运输"",PPAR信号传递"和"HIF-1信号传递"等途径中得到丰富.
鉴定了7个枢纽基因,其中ATP6V0A4在ccRCC组织和细胞系中显示出显著的下调.
低ATP6V0A4表达与ccRCC患者的不良预后和复发相关,它有效地将ccRCC与正常样本区分开来.

结论:

ATP6V0A4在ccRCC中显著下调,并作为潜在的预后生物标志物.
ATP6V0A4可能在ccRCC瘤进展,复发和转移中发挥作用,代表着潜在的治疗点.

关键词:

在 ATP6V0A4 中,生物信息学分析分析生物标志物生物标志物 ccRCCCC 在线观看预后预后预后

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