无活化SARS-CoV-2疫苗在健康成年人中的免疫性和反应性
Yufei Wu1,2,3, Ping Huang3, Mingjie Xu3
1Institute of Medical Sciences, the Second Hospital of Shandong University, Jinan, Shandong, China.
Frontiers in immunology
|August 10, 2023
概括
在无活化疫苗后监测SARS-CoV-2中和抗体,发现随着时间的推移,抗体水平下降. 推进行补充疫苗接种,特别是对于老年人,当抗体水平降低到30%以下时.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行,需要像疫苗接种这样的有效预防策略.
- 疫苗接种后对中和抗体的监测对于确定是否需要补充剂量至关重要.
- 无活化疫苗是对抗SARS-CoV-2感染的关键方法.
研究的目的:
- 通过追踪中和抗体动态来评估非活化SARS-CoV-2疫苗的长期有效性.
- 为了研究T淋巴细胞激活,特别是CD3+T细胞,经过三剂不活化疫苗方案后.
- 评估增剂对抗体水平和T细胞反应的影响.
主要方法:
- 在接种疫苗后两年内对SARS-CoV-2中和抗体进行纵向监测.
- 在三剂不活化疫苗后分析T淋巴细胞激活标记物 (CD25+T细胞).
- 抗体和T细胞水平在不同时间点和跨年龄组的比较.
主要成果:
- 在每次强剂后,观察到SARS-CoV-2中和抗体水平的逐渐降低.
- 第三次疫苗接种后9个月的抗体水平明显高于第二次疫苗接种后6个月 (p<0.0001).
- 在18-35岁年龄组中,特别是在疫苗接种后的晚期阶段,发现CD25+ T细胞表达率更高.
结论:
- CD25是淋巴细胞激活和记忆T细胞的标志物,在接种疫苗后晚些时候显示水平增加.
- 建议对老年人进行补充疫苗接种,并定期监测中和抗体.
- 当抗体抑制率低于30%时,应给予强剂.
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