德尔塔变种和原始SARS-CoV-2感染患者之间病毒流放时间的差异
Fanglin Li1,2, Jiayi Deng1, Canbin Xie1
1Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Frontiers in public health
|August 10, 2023
概括
与原来的SARS-CoV-2相比,COVID-19的Delta变种引起的症状较少,但病毒的流放时间较长. 较低的淋巴细胞计数与德尔塔变种感染的长时间流产有关.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- COVID-19 流行病的特点是出现了许多SARS-CoV-2 变种.
- 德尔塔变种以其高传染性而闻名.
- 有限的数据存在于德尔塔变种感染的病毒流放持续时间.
研究的目的:
- 为了比较感染COVID-19德尔塔变种和原始SARS-CoV-2菌株的患者之间的临床特征和病毒流放时间.
- 为了识别与延长病毒流放在三角洲变种感染相关的因素.
主要方法:
- 一项比较研究涉及56名患有Delta变种的患者和56名原始SARS-CoV-2的患者,根据年龄和性别进行了匹配.
- 分析基线特征,实验室发现和病毒泄漏持续时间.
- 使用了包括相关性和多重线性回归在内的统计方法.
主要成果:
- 德尔塔变种患者的症状显著减少 (如发烧,疲劳,厌食症,呼吸短促,腹) 和肺炎的发病率在胸部CT上较低.
- 与原来的SARS-CoV-2组 (18.5天) 相比,在Delta变种组 (41.5天) 病毒流出时间明显更长.
- 病毒泄漏时间与病毒菌株和血清肌素正相关,与淋巴细胞计数,总胆红素和低密度脂蛋白负相关.
结论:
- 感染Delta变种的COVID-19患者出现了较轻的症状,但经历了长时间的病毒泄漏.
- 德尔塔变种本身和较低的淋巴细胞计数被确定为延长病毒泄漏时间的独立风险因素.
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