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在复发性口腔口腔炎 (RAS) 中,唾液胺合成酶1 (CERS1) 的表达:一个跨部门机构研究

Sangamithra Surendran¹, Pratibha Ramani¹, Karthikeyan Ramalingam¹

¹Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.

|August 10, 2023

概括

与健康个体相比,复发性口腔口炎 (RAS) 患者的唾液胺合成酶1 (CERS1) 水平较低. 需要进行进一步的研究,以澄清CERS1在RAS.的病变发生过程中的作用.

科学领域:

口腔医学是指口腔医学.
生物化学生物化学
细胞生物学细胞生物学

背景情况:

亡的增加有助于的形成,而胺 (CER) 则与亡信号相关.
复发性口腔口腔炎 (RAS) 是一种常见的口腔疾病,其病因不明.
胺合成酶1 (CERS1) 产生C18 CER,其在RAS病原发生中的作用需要研究.

研究的目的:

评估和比较RAS患者和健康对照患者的唾液CERS1表达.

主要方法:

从30名参与者 (15名RAS患者,15名健康对照) 收集了唾液样本.
与酶相关的免疫吸收试验 (ELISA) 用于测量CERS1水平.
统计分析包括千平方和独立t测试 (p<0.05).

主要成果:

在所有参与者的唾液中检测到CERS1.
在RAS患者 (7.6 pg/ml) 中,唾液CERS1水平低于健康个体 (8.3 pg/ml).
这种CERS1水平的差异没有达到统计学意义.

结论:

在RAS患者中,唾液CERS1水平呈现下降趋势.
在RAS中CERS1的确切病原遗传作用需要进一步的研究.

关键词:

性的的.灭症 (apoptosis) 是一种死亡的过程.陶化物是一种陶.胺合成酶1的使用复发性口腔炎的复发性口腔炎.这是唾液,唾液.唾液分析唾液分析

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