神经学新生儿疹简单病毒感染的神经系统的许多面孔
Fadi Shahoud1, Mobeen H Rathore1, Chetan C Shah2
1Pediatrics/Infectious Diseases, University of Florida College of Medicine, Jacksonville, USA.
Cureus
|August 10, 2023
概括
新生儿简单疹病毒 (HSV) 感染可能严重影响中枢神经系统 (CNS). 早期诊断和治疗至关重要,但预后差异很大,即使有及时的医疗护理.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 新生儿简单疹病毒 (HSV) 感染是一种罕见但严重的疾病,具有潜在的破坏性神经后果.
- 中枢神经系统 (CNS) 的参与是新生儿HSV的一个重大问题,导致不同的临床表现和结果.
研究的目的:
- 探索中枢神经系统参与新生儿HSV感染的各种表现.
- 突出与这种疾病相关的诊断和治疗挑战.
- 提出案例研究,说明临床特征和结果的范围.
主要方法:
- 对三名新生儿的病例系列分析,中枢神经系统因HSV感染而受到影响.
- 对临床表现,诊断评估,治疗策略和患者结果的审查.
- 对不同病例的临床特征和预后进行比较.
主要成果:
- 案例1:一个三周大的男性患有严重的HSV脑膜炎,经历了治疗反应不佳和死亡率.
- 案例2和3:较年轻的新生儿患有传播的HSV感染和皮肤,眼睛和口腔 (SEM) 病变,尽管中枢神经系统参与,但在早期呈现和治疗时具有有利的结果.
- 临床表现范围从非特异性症状到明显的神经症状,强调诊断复杂性.
结论:
- 新生儿HSV中中枢神经系统表现的广泛范围需要高的怀疑指数用于早期诊断.
- 及时和全面的评估对于适当的治疗启动至关重要.
- 尽管及时进行干预,但新生儿中枢神经系统感染的HSV的预后仍然不稳定,有些病例前景不佳.
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