甲酸暴露和卵巢功能障碍在子宫内膜异位症的风险:人类和动物数据
Huan Yi1, Huamin Wu2, Wenbin Zhu1
1National Key Gynecology Clinical Specialty Construction Unit of China, Fujian Provincial Key Gynecology Clinical Specialty, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Frontiers in cell and developmental biology
|August 10, 2023
概括
暴露于甲酸盐,特别是甲基甲酸盐 (DEHP),与子宫内膜异位症和卵巢功能障碍有关. 尿酸水平可能有助于诊断子宫内膜异位症和评估生殖预后.
科学领域:
- 环境健康 环境健康
- 生殖内分泌学 生殖内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 子宫内膜异位症是一种影响生殖年龄妇女的疾病.
- 酸盐是环境中常见的内分泌干扰化学物质.
- 甲酸盐暴露与子宫内膜异位症中的卵巢功能障碍之间的联系需要进一步调查.
研究的目的:
- 调查甲酸盐暴露与子宫内膜异位症妇女的卵巢功能障碍之间的联系.
- 通过人类和动物模型探索潜在的机制,以这种关联为基础.
- 评估尿甲酸代谢物对子宫内膜异位症的诊断潜力.
主要方法:
- 一项涉及107名患有子宫内膜异位症的妇女和70名对照者的病例控制研究.
- 使用气体染色学-质谱学量化尿液中的10个甲酸代谢物的量化.
- 在体内对大鼠暴露于二甲基甲酸盐 (DEHP) 的研究,以评估对生殖参数和卵巢功能的影响.
- 对大鼠卵巢组织进行生物信息学分析,以确定潜在的分子通路.
主要成果:
- 在患有子宫内膜异位症的女性中,尿液中的多重甲酸盐含量,包括DEHP,显著更高.
- 确定DEHP是子宫内膜异位症的重要危险因素 (OR: 11.0).
- 在大鼠中,DEHP暴露导致卵巢和子宫质量下降,干扰雌激素周期,并以剂量依赖的方式降低抗穆勒尔激素 (AMH) 水平.
- 生物信息学揭示了大鼠卵巢中类固醇生物合成途径中基因的上调.
结论:
- 酸盐暴露,尤其是DEHP,与子宫内膜异位症有关,并对卵巢功能和生殖预后产生负面影响.
- 类固醇生物合成途径可能与甲酸诱导的卵巢功能障碍有关.
- 尿液甲酸盐检测显示,作为一种新的子宫内膜异位症诊断生物标志物具有前景.
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