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证明DRD2基因是奖励缺陷综合征 (RDS) 的决定因素

Kenneth Blum^1,2,3,4,5,6, Abdala Bowirrat¹, Igor Elman⁷

¹Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel.

Clinical and experimental psychology

|August 10, 2023

概括

DRD2基因,特别是Taq A1变体,与严重的酒精和成风险密切相关. 遗传上风险严重性 (GARS) 测试有助于识别这些风险,支持奖励缺陷综合征假设.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
精神病学是一个精神病学.

背景情况:

自1990年以来出版的超过11,495篇成精神病学文章.
遗传上风险严重性 (GARS) 测试在识别奖励缺陷行为方面显示出临床相关性.
早期的研究将DRD2基因多态与酒精精神联系起来,但发现是混合的.

研究的目的:

调查DRD2基因与成之间的关联,特别是酒精使用障碍 (AUD).
澄清DRD2基因多态性在奖励缺陷综合征 (RDS) 中的作用.

主要方法:

62项关于DRD2 rs 1800497和AUD的研究的元分析.
检查DRD2基因单双型块和AUD/海洛因依赖的检查.
关于抑郁症,自杀和物质使用障碍 (SUD) 的全基因组协会研究 (GWAS).

主要成果:

一项元分析证实了DRD2 rs 1800497和AUD之间存在显著的关联.
DRD2 A1等位基因单基因组型与AUD和海洛因依赖有关.
GWAS研究证实了DRD2 Taq A1等位基因与严重的酒和自杀行为 (P=1.77 × 10−7) 的关联.
DRD2是多种物质SUD的顶级基因信号 (P=7.9 × 10−12).

结论:

DRD2基因及其多态性是奖励缺陷综合征 (RDS) 的重要决定因素.
GWAS的发现应该解决关于DRD2在成中的作用的争议.
GARS测试是评估与遗传倾向相关的成风险的一个有价值的工具.

关键词:

候选基因是一个候选基因.这种基因是DRD2基因.在GWAS中,GWAS就是GWAS.这是一种低多巴胺激应症.多态形态的多态化奖励缺乏和成和非成行为.

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