在接受全关节置换术的患者中,异构和自身输血对免疫功能的影响
Zong-Zheng Han1,2, Miao Li2, Yong Zhang3
1Graduate School of Jinzhou Medical University Jinzhou 121000, Liaoning, China.
American journal of translational research
|August 10, 2023
概括
自主输血,使用患者自己的血液,更好地保持免疫功能,并减少关节置换后的炎症,而不是同源输血. 这一发现支持自输血作为接受全关节整形手术的患者更安全的替代方案.
科学领域:
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
- 整形外科手术 整形外科手术
背景情况:
- 全基因输血可以调节免疫功能并增加术后炎症.
- 自主输血是异构输血的替代方案,但其对免疫反应的影响需要进一步评估.
研究的目的:
- 为了比较异构与自身输血对免疫功能和手术后炎症的影响,在接受关节完全置换的患者中.
- 为了评估自然杀手细胞细胞毒性,T淋巴细胞子集和输血后炎症标记物的变化.
主要方法:
- 对60名关节整形术患者进行了回顾性分析.
- 患者被分为自主 (自动组) 和异构 (异构组) 输血组 (每组n=30).
- 免疫标记物 (NKCC,IL-2,CD3+,CD4+,IgE) 和炎症标记物 (WBC,NP,CRP) 在输血后进行测量.
主要成果:
- 自体组在第二天显示出明显更高的自然杀手细胞细胞毒性 (NKCC),与全基组相比.
- 细胞免疫标记物,包括CD3+和CD4+T细胞,在自身组显著更高.
- 输血后,自身免疫标志物免疫球蛋白E (IgE) 的水平在输血后的自身免疫组中明显较低.
结论:
- 自动输血是全关节整形术后全基因输血的安全有效替代方案.
- 与全基输血相比,自身输血更好地保持了术后免疫功能.
- 自体输血可以减少对异性输血所观察到的对免疫功能的负面影响.
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