在常规临床实践中,评估乳腺癌患者对辅助激素治疗的坚持
Natalia Camejo1, Cecilia Castillo1, Clara Tambasco1
1Department of Clinical Oncology, School of Medicine, University of Uruguay, Montevideo, Uruguay.
World journal of oncology
|August 10, 2023
概括
对乳腺癌 (BC) 进行激素治疗 (HT) 的坚持对于整体生存 (OS) 至关重要. 这项研究发现,19%的患者不坚持,年龄较大与更好的坚持有关,突出了需要改进策略的需要.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 辅助激素治疗 (HT) 在激素受体阳性乳腺癌 (BC) 中显著改善整体存活率 (OS).
- 报告了高比例的非坚持内分泌治疗 (31.0-73.0%),影响治疗疗效.
- 在常规临床实践中评估HT的坚持对于了解现实患者的结果至关重要.
研究的目的:
- 在现实临床环境中评估辅助激素治疗 (HT) 的坚持.
- 确定与乳腺癌患者的HT坚持相关的因素.
- 为改善患者坚持治疗和治疗结果的策略提供信息.
主要方法:
- 分析了一组118名患有0-III期BC的患者,他们在2017-2019年期间接受了HT治疗.
- 使用药物持有率 (MPR ≥0.80) 和莫里斯基-格林量表来衡量药物持有率.
- 后勤回归和费舍尔精确测试评估了坚持和患者/治疗特征之间的关联.
主要成果:
- 对HT的2年坚持率为81.0%,其中19.0%的患者表现出不坚持.
- 年龄较大与较高的坚持显著相关 (P = 0.03,OR = 0.96对于不坚持).
- 坚持并没有与多药学有关,但家庭主妇和退休妇女对芳酶抑制剂 (AIs) 的坚持更大.
结论:
- 在乳腺癌患者中,HT的真实遵守率为81.0%,尽管治疗耐受性良好且免费.
- 年龄较大是一个更好的坚持的预测因素,这表明针对年轻患者可能需要量身定制的干预措施.
- 药房和瘤服务之间的协作努力对于开发增强HT坚持和改善患者运作系统的策略至关重要.
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