塔卡亚苏动脉炎和性结肠炎中常见的自身抗体:一种可能的病理生理学,包括血管炎症中的肠血管连接
1Department of Rheumatology, Tohoku University Hospital, Sendai, Japan.
JMA journal
|August 10, 2023
概括
塔卡亚苏动脉炎 (TAK) 涉及血管炎症,其发源于血管. 异常的B细胞激活和自身抗体可能会驱动TAK和性结肠炎 (UC) 的发病,这表明肠血管炎症的联系.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
背景情况:
- 塔卡亚苏动脉炎 (TAK) 是一种主要影响年轻女性的大血管血管炎,其确切的病理机制正在调查中.
- 血管管炎症被假定是最初的事件,导致血管壁损伤,狭窄或扩张.
- 虽然T细胞和骨髓状细胞参与其中,但B细胞在TAK病原发生中的作用越来越被认可.
研究的目的:
- 审查目前对TAK病理机制的理解,重点关注B细胞参与和自身抗体.
- 探索TAK和性结肠炎 (UC) 之间的联系,强调共享的病理生理路径.
- 讨论肠血管炎症的新兴概念和肠道微生物群的作用.
主要方法:
- 关于高山氏动脉炎和性结肠炎的最新科学文献的综述.
- 分析B细胞,自身抗体 (例如,抗内皮蛋白C受体) 和T细胞在血管炎症中的作用.
- 检查肠道微生物群,失生症和全身血管炎症之间的关联.
主要成果:
- 在TAK中发现了两种自身抗体,可能维持血管炎症.
- 在TAK和UC中发现的抗内皮蛋白C受体自身抗体,表明共同的病理生理学.
- 有证据表明异常B细胞激活是这些疾病中潜在的共同机制.
结论:
- B细胞和特定的自身抗体在塔卡亚苏动脉炎的发病过程中发挥着重要作用.
- TAK和UC之间的遗传和临床关联表明共享的潜在机制,可能涉及异常B细胞激活.
- 研究TAK和UC中的肠道微生物群等常见因素可以阐明肠血管炎症轴.
相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
215
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
215
Autoimmune Disorders
494
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
494
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
173
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
173
Gastritis-II: Pathophysiology
375
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
375
Drugs for Treatment of Ulcerative Colitis in IBD
173
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
173
Chronic Bowel Disorders: Introduction
485
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
485


