关于维生素D可接受的上限摄入量水平的科学意见,包括计算单水化合物的转换因子
EFSA journal. European Food Safety Authority
|August 10, 2023
概括
欧洲食品安全局确定了维生素D的新的可容忍上限摄入量 (UL),为成人和青少年定为100微克/天,儿童为50微克/天. 建议将2.5的转换系数用于卡尔西单酸盐的标签.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 食品安全 食品安全
背景情况:
- 欧洲委员会要求对维生素D的可容忍上限摄入量 (UL) 进行修订.
- 维生素D包括埃尔戈化醇 (D2),胆化醇 (D3) 和单水化合物.
- 现有的关于维生素D生物可用性和不良影响的数据需要系统审查.
研究的目的:
- 修订维生素D的可容忍上限摄入量 (UL).
- 提出一个转换系数 (CF) 卡尔西单酸盐的标签.
- 评估过量摄入维生素D对健康的不良影响,包括高血和肌肉骨健康.
主要方法:
- 对卡尔西单水合物与维生素D3的生物可用性进行了系统的文献审查.
- 评估过多的维生素D摄入对健康的优先不利影响.
- 利用随机对照试验来确定最低观察到的不良影响水平 (LOAEL).
主要成果:
- 建议卡尔单水化合物的转化因子 (CF) 为2.5用于标签.
- 持续性高性尿被确定为确定UL的关键终点.
- 已确定成人和青少年每天100微克维生素D相当量 (VDE) 的UL,儿童 (1-10岁) 每天50微克VDE.
结论:
- 拟议的 UL 旨在防止过度摄入维生素 D 的不良健康影响.
- 欧洲人口不太可能超过这些ULs,除了高剂量补充剂使用者.
- 已建立的UL和CF为安全的维生素D摄入量和准确的食品标签提供了指导.
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