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在美国成年人中循环的N-终端亲脑型尿素 (NT-proBNP) 的种族和种族差异
Yvonne Commodore-Mensah1,2,3, Dan Wang1,2, Yein Jeon1
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
American journal of preventive cardiology
|August 10, 2023
概括
在N-终端亲大脑类型尿素 (NT-proBNP) 水平存在种族和种族差异,与白人成年人相比,在黑人和墨西哥裔美国人中观察到的水平较低. 即使考虑到心血管风险因素,这些差异仍然存在.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 健康差异 在健康上的差异
背景情况:
- N-终端前脑类型尿素 (NT-proBNP) 是诊断心力衰竭的一个关键生物标志物.
- 目前正在讨论NT-proBNP水平的种族和民族差异的解释.
- 了解这些差异对于在不同人群中进行准确的临床评估至关重要.
研究的目的:
- 在美国成年人口中调查和量化NT-proBNP水平的种族和民族差异.
- 确定这些差异是否受社会人口和心血管风险因素的影响.
- 探索NT-proBNP变异的潜在非心脏代谢决定因素.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (1999-2004) 的横截面分析.
- 包括以前没有心血管疾病的非西班牙裔白人,非西班牙裔黑人和墨西哥裔美国人 (≥20岁) 成年人.
- 应用线性和逻辑回归模型来评估种族/种族和NT-proBNP之间的关联.
主要成果:
- 与白人成年人 (49.1 pg/mL) 相比,黑人 (29.3 pg/mL) 和墨西哥裔美国人 (28.3 pg/mL) 的中位NT-proBNP水平明显较低.
- 经过调整后的分析显示,NT-proBNP在黑人成年人中降低了34.4%,在墨西哥裔美国人成年人中降低了22.8%,而不是白人成年人.
- 在一个年轻,健康的小组中,一致的发现表明非心脏代谢因素有助于这些观察到的种族和种族差异.
结论:
- 与白人成年人相比,黑人和墨西哥裔美国人的NT-proBNP水平明显较低,独立于心脏代谢风险.
- 虽然种族/种族是遗传变异的不完美代理,但这些发现对心力衰竭管理有潜在的临床影响.
- 在多样化的种群中进行进一步的研究是必不可少的,以阐明NT-proBNP变异性的生物学基础.
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