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牙纸干细胞用于重建骨缺陷:系统性审查和元分析

Neda Moeenzade¹, Mohsen Naseri², Fereshteh Osmani³

¹Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.

Journal of dental research, dental clinics, dental prospects

|August 10, 2023

概括

牙纤维干细胞 (DPSCs) 显著增强牙植入物的骨再生. 这次审查证实了它们在改善骨质和骨质量的有效性,用于膜脊梁重建.

科学领域:

再生医学是一种再生医学.
生物材料科学生物材料科学
牙科植入物学牙科植入物学

背景情况:

对于牙科植入物而言,膜脊骨的重建存在重大挑战.
牙髓干细胞 (DPSCs) 为未来的骨再生疗法提供了一个有前途的途径.

研究的目的:

调查DPSCs在促进牙科应用的骨再生方面的有效性.
系统地审查和对DPSC介导骨再生的现有临床前研究进行元分析.

主要方法:

在PubMed,EMBASE和Scopus数据库中进行了全面的文献搜索,截至2022年4月21日.
纳入标准侧重于体内研究,报告新骨体积和骨面积的定量数据.
研究质量是使用Cochrane的检查清单来评估的,最终包括了23项研究.

主要成果:

对70项研究的元分析表明,DPSC显著改善了新的骨面积 (SMD=2.40,P<0.00001).
对14项研究的元分析表明,DPSC显著增加了新的骨体积 (SMD=1.85,P=0.0003).
这两项分析都表明,与对照组相比,骨组织再生具有统计学上显著的积极影响.

结论:

在临床前研究中,DPSC对复杂骨组织再生产生了显著的积极影响.
需要进一步进行多样化的临床前研究,以促进更强大的元分析和临床翻译.

关键词:

骨再生骨的再生牙纸是一种牙纸.介质细胞干细胞介质细胞干细胞进行元分析分析.组织工程是组织工程.

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