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易于制造Nishamalaki churna介导的银纳米颗粒与抗菌应用

Bhavna Ghosh^1,2, Anindya Bose¹, Ankita Parmanik¹

¹School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India.

|August 10, 2023

概括

绿色合成的银纳米粒子通过破坏细菌生物膜,有效地对抗抗生素耐药性. 这项研究表明它们具有强大的抗菌,抗氧化和抗炎性质,为一个主要的医疗威胁提供了有希望的解决方案.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
微生物学微生物学

背景情况:

抗菌素耐药性 (AMR) 是一个关键的全球健康挑战.
细菌生物膜通过保护细菌免受抗微生物药物的作用,对抗菌素耐药性有显著的贡献.
银纳米粒子 (AgNPs) 因其固有的抗菌特性而被探索其克服抗菌素耐药性的潜力.

研究的目的:

为了绿色合成银纳米颗粒 (AgNPs) 使用尼沙马拉基丘纳提取物.
为了描述合成的AgNPs.
评估AgNP对抗抗生素耐药细菌及其生物膜的疗效.

主要方法:

使用水性Nishamalaki churna提取物进行AgNP的绿色合成.
使用UV-Vis,FT-IR,SEM,XRD和DLS-Zeta潜在分析对AgNP进行物理化学表征.
抗菌和抗菌膜对*金黄色葡萄球菌*和空气真菌*进行抗菌和抗菌膜分析.

主要成果:

成功合成了大小介于30-80nm的球形AgNP.
合成的AgNP表现出强大的抗菌活性,可以对抗*S. aureus*和*P. aeruginosa*.
观察到细菌生物膜的有效破坏,以及显著的抗氧化和抗炎作用.

结论:

尼沙马拉基丘纳提取物促进了有效的银纳米颗粒的绿色合成.
这些AgNP显示出通过向细菌生物膜来对抗AMR的巨大潜力.
额外的抗氧化和抗炎性质使得这些AgNP成为新型抗菌疗法的有希望的候选者.

关键词:

阿姆拉基阿姆拉基是什么意思抗微生物耐药性抗微生物耐药性这是一种阿育吠陀配方.生物膜是一种生物膜.绿色合成是一种绿色合成.黄是一种黄.

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