与FT3相比,TT3是一个更实用的指标,用于评估与FT3相比,甲状腺老年人的甲状腺和甲状腺激素之间的关系
Jihai Chen1,2, Lijun Wei2, Xiaoxia Zhu2
1Department of Geriatric, Geriatric Hospital of Nanjing Medical University, Nanjing, 210024, People's Republic of China.
Clinical interventions in aging
|August 10, 2023
概括
低总三甲状腺素 (TT3) 水平与老年 euthyroid个体的肉症有关. 保持较高的TT3度可能有助于预防肉症,并保持老年人的肌肉力量.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 肌肉生理学 肌肉生理学
背景情况:
- 萨科佩尼亚是一种常见的与年龄相关的疾病.
- 甲状腺激素 (THs) 可能在肉类的发病过程中发挥作用,但之前的发现是不一致的.
- 这项研究调查了中国老年无甲状腺患者的THs和肉症.
研究的目的:
- 为了检查甲状腺激素和老年 euthyroid 中华人的sarcopenia之间的关联.
- 为了确定特定的甲状腺激素指标相关的萨尔科佩尼亚在这个人群中.
主要方法:
- 评估了309名老年甲状腺症患者 (平均年龄为85.19岁).
- 参与者根据肉症的严重程度 (AWGS 2019标准) 被分为四组.
- 测量了血清甲状腺激素水平 (TT3,FT3,TT4,FT4,TSH,rt3,TBG),肌肉质量,手握力 (HG) 和步行速度 (GS).
主要成果:
- 萨科佩尼亚组的年龄和FRAIL分数较高,FT3和TT3水平明显较低.
- 部分相关性显示FT3,TT3和TSH与HG的正相关性,TT3与GS的正相关性.
- 多变量回归表明TT3与肌肉强度正相关,与肉症风险负相关.
结论:
- 低总三甲氨酸 (TT3) 水平和肉症之间存在显著的关联.
- 在正常范围内保持较高的TT3度可能有利于老年人治疗肉症.
- 与FT3相比,TT3是一个比FT3更稳定,更实用的指标,用于评估甲状腺激素与甲状腺癌的老年人之间的关系.
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